Tuesday, 9 February 2016

Widnes SciBar 10th February 2016

The next meeting of Widnes SciBar will be at 7:30 pm on Wed 10th Feb in the Trafalgar Room (upstairs) at the Hillcrest Hotel.

Alex Brown 

National Nuclear Laboratory (Warrington)

Modelling to help clean up Sellafield

You can read more here.
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An age old problem?

Photo of Dr Joao Pedro De MagalhaesJanuary's Sci Bar was delivered by Dr Joao Pedro De Magalhaes from the University of Liverpool's Institute of Integrative Biology. The topic was close to the hearts (perhaps literally) of everyone in the audience, which was, as usual, a full house. Bob Roach thanked Joao (following a group discussion on consensus pronunciation), as Pedro, for agreeing by return of email to turn up so close to New Year. The aim of the talk was to explore what could be learned from comparing the genetics of ageing in man and in a wide range of organisms, from whales and mice, to the simpler eukaryotes: Baker's yeast and Caenorhabditis elegans. In addition Joao discussed the types of genes that seemed to be associated with longevity. In keeping with the influence of epigenetics in contemporary clinical and behavioural research, there was a discussion of the environmental factors, including diet, that might influence life-span.

Using examples drawn from a wide spectrum of evolutionary examples, Joao began with a statement of the central dogma of Molecular Biology, originally proposed by Francis Crick: DNA makes RNA makes protein. It was in this context that he explained how mutations in the genome could give rise to proteins of modified function, which in turn could potentially influence life-span. What was striking from one of Joao's slides, was the "investment" that simple model organisms make in age-related processes. For example, out of around 6 000 genes, the simple unicellular yeast has over 800 genes linked in some way to life-span. Clearly, many of these genes will provide essential functions that impact upon ageing, but are probably there to provide other key roles in general growth and reproduction of yeast. And what of the role of non-coding RNAs in these mechanisms?

The gene associated with the maintenance of the tips of chromosomes, or telomeres, was also discussed as an important factor in cellular aging, with Dolly the Sheep owing its early onset ageing characteristics being partly a result of a dysfunctional telomerase activity. Companies like Geron in California who focus on understanding the genetic factors influencing life-span, seem to provide "wealthy" citizens the opportunity to extend life and in particular the quality of life at an advanced age.

There were two issues raised in the presentation that seemed to capture the audience's attention. The first was a study of the correlation between height and life expectancy and the second was the explanation behind the exceptional longevity of whales. The gene encoding the growth hormone receptor in both mice and men, when mutated can supply a form of "resistance" to cancer and diseases in general and indirectly promotes life-span. Whilst the speaker acknowledged that the sample size and its restricted nature (a self contained US community), made extrapolation questionable; the trend was intriguingly clear in the particular sample  tested.
 
A bowhead whale diving.The Bowhead whale has proved a rich seem of longevity related research but, suggestions about the age estimates are not easy to verify; notwithstanding old harpoon scars! However, the superb, online resource provided by Joao and his colleagues is surely the way forward for unlocking teh potential of comparative genomics in improving the quality of life as the mean life-span of humans slowly increases!

You can find access to the Bowhead Whale Genome Project here.

Wednesday, 13 January 2016

Next Widnes Sci Bar Meeting

Widnes Sci Bar: Talking science in a relaxed setting

What? A scientist talks about their research and then you can discuss it and ask questions

Where? Hillcrest Hotel, Cronton Lane,Widnes, WA8 9AR

Who for? Widnes Sci Bar is for anyone with an interest in science or a wish to know more about science.


When? 7:30 pm, Wed 13th Jan 2016

This week's Sci Bar will include a presentation by

Dr Joao Pedro De Magalhaes



from the Institute of Integrative Biology, the University of Liverpool, entitled: 



Genes regulating aging and the quest for immortality

Photo of Dr Joao Pedro De MagalhaesAbstract: Hundreds of genes are now known to regulate aging and have been shown to increase longevity by up to ten fold in animal models. Drugs mimicking the longevity effects of these genes are now being developed. Studies of species with exceptional longevity - like bowhead whales, or disease resistance - like naked mole-rats, may help to improve human health and prevent diseases.

 


Presented by Friends of Catalyst & the Catalyst Science Discovery Centre

Tuesday, 8 December 2015

Announcing: Toxic Tales and Animal Evolution!

The next meeting of Widnes SciBar will be as follows:-
 
7:30 pm on Wed 9th Dec in the Trafalgar Room at the Hillcrest Hotel, Cronton Lane,Widnes, WA8 9AR.
 
Please note that we recently changed to a different room - the Trafalgar room is on the first floor.
 
Kevin Arbuckle from the Department of Evolutionary Biology, Zoology and Ecology, University of Liverpool, will talk about:-
 
Telling Toxic Tales - Chemical Warfare in Animal Evolution.
 
Here is Kevin’s description of his talk:-
 
Kevin ArbuckleVenomous and poisonous animals inspire fear and fascination. Animals from across the ‘tree of life’ have used toxic and repellent chemicals to catch prey and avoid becoming a meal themselves. Not only do many of these species advertise their defence with beautiful colours but toxins may even shape the evolution of the animals that possess them. 

His University Home Page is here 



 

Bob Roach 30th November 2015.

The Asteroid Threat!

The Asteroid Threat

Widnes SciBar - 11th Nov 2015
 
Andy Newsam,  Professor of Astronomy Education and Engagement, Liverpool John Moores University.

Asteroids are small rocky objects orbiting the Sun. Although most asteroids in the Solar System are in the Asteroid belt between Mars and Jupiter, not all are restricted to it. Those not in the Belt could be a threat to Earth, as could those that are occasionally pulled out of that Belt by the gravity of Jupiter - these are called ‘Trogans’. As a result, there is a small possibility of one hitting the Earth but, if it did, the consequences could be massive. It is these ‘near Earth objects’ that astrophysicists are interested in. 

The craters peppering the Moon are a sign of how asteroids can come into the vicinity of the Earth - the age of these craters can be estimated from the amount of weathering that has taken place. There are far fewer known craters on the Earth but not all asteroid strikes will have left an identifiable crater - some will have landed in an ocean or vegetation may have obscured some craters on land.

An asteroid created the Barringer (or Meteor) Crater in Arizona about 50,000 years ago - the crater is about 1200 m across and 170 m deep. The asteroid was about 40 metres diameter - tiny as asteroids go. Such small asteroids are not yet detectable but that is not a great concern because the damage caused by them, whilst significant for many miles around, is not potentially
catastrophic for life on the Earth. 

Craters
In 2004 there was a ‘near miss’ when an asteroid of about 900 metres diameter passed between the Earth & Moon. If it had hit land on Earth it would have caused a crater about ‘the size of Wales’, throwing up a massive dust plume that would spread rapidly in the higher atmosphere and could block out sunlight and  so stop plant growth. Such an asteroid landing in an ocean would trigger a massive tsunami that would travel round the Earth. The Near Earth Asteroid Rendezvous (NEAR) space mission that landed on asteroid Eros in 2000 and the Rosetta Mission & its Philea probe landing on Comet 67P in 2014 have greatly increased the scientific understanding of asteroids. Previously, knowledge was limited largely to observing them from Earth and the evidence obtained from them hitting the Earth.

In brief, the risk of a large asteroid striking the Earth in our lifetime is small – they tend to occur about every 20 to 30 million years. However, the consequences of such a strike would be massive. Shown right is the Barringer Meteor/Crater in Arizona.
Andy described how scientists are seeking how to identify asteroids that pose a threat, how to track them and make them safe.

Detection. Most of the detecting work has now been done - it is believed that about 90% have been identified.

Liverpool Telescope, La Palma
Tracking. Tracking is currently the main focus of activity. It is being done by a combination of amateur observation (e.g. the privately run Spaceguard Centre in Mid-Wales) & large telescopes that are needed to track the smaller & more distant asteroids. Andy and his colleagues use Liverpool Telescope on the island of La Palma - it is the world’s largest fully robotic telescope, i.e. it can be operated from Liverpool. With such telescopes it is possible to pick out an asteroid from many stars by comparing images of the same area of sky taken some time apart - in contrast to the stars, an asteroid will have moved. Much of assessing is done by software but as it can only be relied upon to detect  95% of asteroids, the process isn’t perfect.

From these images, the course of an asteroid can be predicted for up to 100 years. If that suggests a danger to the Earth, the asteroid’s track will be kept under review - in time, a more accurate prediction of an asteroid’s risk can be made, often with a decision to remove it from the risk list.

As part of his ‘public engagement’ role, Andy spoke about involving children in identifying asteroids from two or more time-separated images from the Liverpool Telescope. A 12 year old spotted a faint trace that the professionals hadn’t noticed!

Making Safe. As yet we have no means of ‘making safe’ n asteroid heading our way. Use a nuclear bomb to blow them up? Apart from the practicalities of doing it, this could cause the Earth to be bombarded with broken lumps of the asteroid. Other possibilities include deflecting the asteroid’s path such as with the gravitational effect of a nearby massive weight (a ’gravity tractor) or painting one side white. If tracking identified a threat 20 years off, would there be the time & motivation to find a way to try to prevent a collision, to practice it & then to use it to make the Earth safe? 

Further Information

Andy is Director of the National Schools Observatory; ‘an online resource that brings the Universe  into the classroom’:- http://www.schoolsobservatory.org.uk/
Video of Andy actively engaging young people into science. Worth watching; Andy talks about finding asteroids from 42 minutes:- http://www.iop.org/resources/videos/education/schools-and-colleges-lecture/page_50047.html
Spaceguard Centre, Mid-Wales:- http://spaceguardcentre.com/

Bob Roach       30th Nov 2015